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Maternal Vitamin D supplementation significantly improved maternal plasma 25(OH)D but not infant 25(OH)D or bone turnover marker

Maternal Vitamin D supplementation significantly improved maternal plasma 25(OH)D but not infant 25(OH)D or bone turnover marker

Name:
Meron Wondimagegnhu

Department:
Nutritional Sciences

Abstract:
We have reported Vitamin D insufficiency in Ethiopian women despite proximity to the equator, but responses to oral vitamin D supplementation in this population are not known. The aim of the study was to determine the effect of vitamin D3 supplmentation on maternal and infant plasma 25(OH)D concentrations and markers of bone turnover. We conducted a randomized, placebo controlled, double blind trial (NCT02210884) in Sidama Zone (7oN, 38oE), Southern Ethiopia. Lactating women (n=126) were enrolled within 2 weeks postpartum and were randomized to receive vitamin D3 (15,000 IU/week) or placebo for 12 months. Plasma 25(OH)D, bone specific alkaline phosphatase (BAP), osteocalcin (OC) and C-telopeptide for type 1 collagen (CTX) were determined. Skin reflectance, dietary intake and individual UVB exposure also were measured. Median (IQR) 25(OH)D concentrations were not significantly different between vitamin D and placebo groups at baseline [47 (37, 57) nmol/L vs 45 (38, 55) nmol/L, p=0.78]. 25(OH)D concentrations were significantly higher in the vitamin D group at one year [109 (93, 121) nmol/L vs 62 (50, 81) nmol/L, p < 0.0001]. All women in the vitamin D group were vitamin D sufficient (> 50 nmol/L) by the end of the study. Furthermore, 95% had attained 25(OH)D concentrations > 75 nmol/L compared to 39% in the placebo group. Infant 25(OH)D concentrations at one year were not significantly different between groups. Maternal BAP and OC concentrations increased between 2 weeks post-partum and 12-month follow up in both groups (P< 0.001). No significant differences by group were seen for all bone turnover markers. Weekly Vitamin D3 (15,000 IU/week) supplementation safely eliminated vitamin D insufficiency in the study population.