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Designing Eumelanin-inspired Antimicrobials that Target Multi-drug Resistant Bacteria

Designing Eumelanin-inspired Antimicrobials that Target Multi-drug Resistant Bacteria

Name:
Santosh Adhikari

Department:
Chemistry

Abstract:
Melanin is one of the most primitive pigments found in living organisms which has profound and fascinating interdisciplinary implications on physics, chemistry, biology and medicine. Eumelanin, the black brown variety of melanin, is insoluble photoprotective pigments of human skin and eyes. It is a heterogeneous network formed by the oxidative polymerization of 5,6-dihydroxyindole and 5,6-dihydroxyindole-2-carboxylic acid. Biocompatible and biodegradable nature and peculiar physicochemical properties of Eumelanin make them promising material in medicine and bioelectronics. Here, we are interested in synthesizing highly active Eumelanin-inspired conjugated oligomers containing aliphatic quaternary ammonium salt that have high potential to possess antimicrobial activity to combat the threats caused by the increasing resistance in pathogenic bacteria to various antimicrobial agents.